Drug repurposing for neuroregeneration in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis
OBJECTIVE To develop and implement an evidence based framework to select, from drugs already licenced, candidate oral neuroprotective drugs to be tested in secondary progressive multiple sclerosis. DESIGN Systematic review of clinical studies of oral putative neuroprotective therapies in MS and four other neurodegenerative diseases with shared pathological features, followed by systematic rev...
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Unlike the peripheral nervous system (PNS) the adult mammalian central nervous system (CNS) does not spontaneously regenerate after injury. Numerous axon-inhibitory molecules are present in the injured CNS and various strategies for overcoming these obstacles and enhancing CNS regeneration had been experimentally developed. Adult neuroregeneration is a complex process, beyond the common knowled...
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Skin cancers are highly prevalent malignancies that affect millions of people worldwide. These include melanomas and nonmelanoma skin cancers. Melanomas are among the most dangerous cancers, while nonmelanoma skin cancers generally exhibit a more benign clinical pattern; however, they may sometimes be aggressive and metastatic. Melanomas typically appear in body regions exposed to the sun, alt...
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In the mid-1980s, a French company geared its efforts toward developing a synthetic steroid capable of blocking the glucocorticoid receptor in order to potentially treat Cushing’s syndrome. Preclinical studies revealed that the compound developed, termed RU-38486, was indeed a potent antiglucocorticoid agent [1], yet with a caveat: if given to pregnant animals, it terminated pregnancy [2-4]. Th...
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Background and Aim: Taking a wide range of medications in Multiple sclerosis (MS) patients can lead to side effects and drug interactions. Therefore, the use of intelligent systems such as drug monitoring systems can help in the effective and timely treatment of MS disease. In this regard, the present study was conducted to design, development, and evaluation of the drug monitoring system for m...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2018
ISSN: 1673-5374
DOI: 10.4103/1673-5374.235242